Quantitation of time-resolved and frequency-resolved optical-spectra for the determination of tissue oxygenation. Sevick, E.M., Chance, B., Leigh, J., Nioka, S. Time-resolved and nonlinear optical imaging for medical applications. Sub-millimeter resolution fluorescence molecular imaging system for small animal imaging. Time resolved reflectance and transmittance for the noninvasive measurement of tissue optical-properties. Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Spectroscopy and imaging with diffusing light. High-resolution near-infrared (nir) imaging of dense scattering media by diffusion tomography. Finite-Element Approach For Modeling Photon Transport In Tissue. In vivo cancer targeting and imaging with semiconductor quantum dots. Gao, X., Cui, Y., Levenson, R.M., Chung, L.W.K. Non-invasive image acquisition and advanced processing in optical bioimaging. It's not just about anatomy: in vivo bioluminescence imaging as an eyepiece into biology. Whole-body optical imaging of green fluorescent protein-expressing tumors and metastases. Near infrared optical imaging system to detect tumor protease activity. Imaging of spontaneous canine mammary tumors using fluorescent contrast agents. Shedding light onto live molecular targets. Molecular imaging: looking at problems, seeing solutions. In vivo imaging of proteolytic enzyme activity using a novel molecular reporter. Advance in contrast agents, reporters, and detection. Green fluorescent protein imaging of tumour growth, metastasis, and angiogenesis in mouse models. Scaling down imaging: molecular mapping of cancer in mice. Molecular imaging of host-pathogen interactions in intact small animals. Advances in in vivo bioluminescence imaging of gene expression. In vivo molecular-genetic imaging: multi-modality nuclear and optical combinations. Molecular imaging in living subjects: seeing fundamental biological processes in a new light. For photonic imaging to fully realize its potential, however, further progress will be needed in refining optical inversion methods and data acquisition techniques. Recent theoretical and instrumentation advances allow the use of large data sets and multiple projections and offer practical systems for quantitative, three-dimensional whole-body images. Photographic methods have been the mainstay for fluorescence and bioluminescence macroscopy in whole animals, but emphasis is shifting to photonic methods that use tomographic principles to noninvasively image optical contrast at depths of several millimeters to centimeters with high sensitivity and sub-millimeter to millimeter resolution. Although much attention has been paid to microscopy, macroscopic imaging has allowed small-animal imaging with larger fields of view (from several millimeters to several centimeters depending on implementation). Optical imaging of live animals has grown into an important tool in biomedical research as advances in photonic technology and reporter strategies have led to widespread exploration of biological processes in vivo.
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